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Cladribine Tablets and COVID-19

• EMD Serono is continuing to conduct safety surveillance to identify and evaluate drug safety risks

• As of 29 June 2020, 46 suspected cases of COVID-19 occurring in patients treated with Cladribine Tablets have been reported to the Merck KGaA, Darmstadt, Germany safety database

• Of these 46 cases, 18 cases are positively confirmed COVID-19

Summary of confirmed cases of COVID-19 in patients
receiving Cladribine Tablets in the Merck safety database

    Cases, n
Total   18
  Female 9
Severity    
  Seriousa 4b
  Non-serious 14
Outcomec,d    
  Recovered/recovering 10
  Not recovered 1
  Fatal 0
  Unknown 7

 

  • Please direct any queries relating to Cladribine Tablets and COVID-19 to the US medical information team.
  • aCases were considered serious if medically significant or if the patient was hospitalized; bNo mechanical ventilation required; c3 patients delayed treatment until symptoms resolved; dat last update

Favorable outcomes after COVID-19 infection in multiple sclerosis patients treated with Cladribine Tablets

Jack D, Nolting A, Galazka A

Mult Scler Relat Disord 2020;102469

https://doi.org/10.1016/j.msard.2020.102469

DJ and AN are employees of Merck KGaA, Darmstadt, Germany. AG is an employee of Merck, Aubonne, Switzerland, a division of Merck KGaA, Darmstadt, Germany.

 

• Letter to the editor reporting outcomes of patients receiving Cladribine Tablets who have contracted COVID-19 and have been reported to the Merck KGaA, Darmstadt, Germany Global Patient Safety Database (data cut-off 29 June 2020)